人才队伍

基本信息

姓名：刘许歌 性别：男

籍贯：河南 许昌 民族：汉

出生年月：1985年10月  政治面貌：党员

学历：博士研究生 毕业院校：中山大学 专业：药物化学

电话：15626235660       邮箱：liuxg7@yeah.net

地址：河南大学 药学院 河南省开封市金明校区475001

教育背景

2014.08 – 2017.06 中山大学 药学院 药物化学专业 博士研究生 理学博士

导师：王洪根 教授/优青

2010.09 – 2013.06 昆明理工大学 生命科学与技术学院 药物化学专业

硕士研究生 医学硕士

导师：张宽仁 教授 沈悦海 教授

2006.09 – 2010.06 华北理工大学 药物制剂专业 理学学士

工作经历

2020.12-今  河南大学药学院 黄河学者特聘教授/硕士生导师

2017.07 – 2020.11    中山大学   特聘研究员

2013.07 – 2014.07   药明康德新药开发有限公司 研究员

研究方向

药物化学，糖化学

发表论文：

1. Xu-Ge Liu* , Qian Yang , Deng-Yin Liu, Jing Liu , Dong-Hang Tan , Yu-Jun Ruan , Peng-Fei Wang, Xiao-Li Wang , Honggen Wang*. Nickel-Catalyzed Reductive Decarboxylative/Deaminative Glycosylation of Activated Aliphatic Acids and Primary Amines. Org. Lett. 2023, 25, 5022–5026.

2. Lin Xiao, Xu-Ge Liu*, Mei-Zhu Bao, Jia-Lin Song , Shao-Yong Chen, Yi-Chuan Zheng, Yan-Zhi Liu, Shang-Shi Zhang.* Cp*Rh(III)-Catalyzed ortho-Alkylation/Alkenylation of Nitroarenes. Org. Lett. 2023, 25, 5185–5190

3. Shao-Yong Chen , Yi-ChuanZheng , Xu-GeLiu*,Jia-LinSong,LinXiao,Shang-Shi Zhang*. Synthesis of Indole-Substituted Trifluoromethyl Sulfonium Ylides by Cp*Rh(III)-Catalyzed Diazo-carbenoid Addition to Trifluoromethylthioether. J. Org. Chem. 2023, 88, 5512−5519.

4. Yi-Chuan Zheng, Bing Shu, Yao-Fu Zeng, Shao-Yong Chen, Jia-Lin Song, Yan-Zhi Liu, Lin Xiao, Xu-Ge Liu*, Xuanxuan Zhang*, Shang-Shi Zhang*.A cascade indazolone-directed Ir(III)- and Rh(III)-catalyzed C(sp2)–H functionalization/[4+2] annulation of 1-arylindazolones with sulfoxonium ylides to access chemically divergent 8H-indazolo [1,2-a]cinnolines. Org. Chem. Front., 2022,9, 5185

5. Shao-Yong Chen, Yi-Chuan Zheng, Xu-Ge Liu*, Jia-Lin Song, Bing Shu, Tao Zheng, Lin Xiao, Shang-Shi Zhang*, Hua Cao*. Indazolones Directed Rh(III)-Catalyzed C−H Amidation of Arenes. Adv. Synth. Catal. 2022. 364, 3302.

6. Hui Xie,  Jia-Lin Song,   Chun-Yong Jiang,  Yan-Xia Huang, Jun-Yi Zeng,   Xu-Ge Liu*, Shang-Shi Zhang * and  Fan Yang*. Thioether-directed Rh(iii)-catalyzed peri-selective acyloxylation of arenes. Org. Biomol. Chem., 2022,20, 565-569

7. Hui Xie, Jin-Yi Liang, Zhuo-Jun Huang, Bing Shu, Yi-Chuan Zheng, Yan-Zhi Liu, Shao-Yong Chen, Xu-Ge Liu* & Shang-Shi Zhang*. Rh(III)-Catalyzed Tandem C(sp2)-H Allylation/N-Alkylation Annulation of Arene Amides with 2-Alkylidenetrimethylene Carbonates. Org. Chem. Front.2021, 8, 6585-6590.

8. Zhan Li‡, Ke-Feng Wang‡, Xin Zhao‡, Huihui Ti, Xu-Ge Liu*, Honggen Wang*. Manganese-Mediated Reductive Functionalization of Active Aliphatic Acids and Primary Amines. Nature Communications, 2020, 11: 5036. (共同通讯 IF 14.919)

9. Xu-Ge Liu, Chu-Jun Zhou, E Lin, Xiang-Lei Han, Shang-Shi Zhang, Qingjiang Li and Honggen Wang*. Decarboxylative Negishi Coupling of Redox-Active Aliphatic Esters with Cobalt Catalysis. Angew. Chem. Int. Ed. 2018, 57, 13096-13100. (IF 15.336)

10. Xu-Ge Liu ‡, Hui Gao ‡, Shang-Shi Zhang, Qingjiang Li, and Honggen Wang*. N-O Bond as External Oxidant in Group 9 Metal Cp*M(III)-Catalyzed Oxidative C−H Coupling Reactions. ACS Catal. 2017, 7, 5078−5086.  (并列一作排第一 IF 13.084)

11.Xu-Ge Liu, Qingjiang Li, Honggen Wang*. (Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Direct Trifluoromethyl-thiolation of Arenes via C−H Activation. Adv. Synth. Catal. 2017. 359, 1942-1946. (IF 5.837)

12. Xu-Ge Liu, Shang-Shi Zhang, Chun-Yong Jiang, Jia-Qiang Wu, Qingjiang Li, Honggen Wang*. Cp*Co(III)-Catalyzed Annulations of 2 Alkenylphenols with CO: Mild Access to Coumarin Derivatives. Org. Lett. 2015, 17, 5404−5407. (IF 6.005)

13. Xu-Ge Liu, Shang-Shi Zhang, Jia-Qiang Wu, Qingjiang Li, Honggen Wang*. Cp*Co(III)-catalyzed direct functionalization of aromatic C–H bonds with α-diazomalonates. Tetrahedron Lett. 2015, 56, 4093–4095. (IF 2.415)

14. Xuge Liu, Zhilin Yang, Ya-Min Li, Fan Yang, Liang Feng, Nengzhong Wang, Debiao Ma, Kwen-Jen Chang, Yuehai Shen*. A practical nickel-catalyzed reductive alkylation of amidophenyl bromides, Tetrahedron. 2014, 70, 9522-9529. (IF 2.457)

15. Yao Liu, Ji-Lin Li, Xu-Ge Liu, Jia-Qiang Wu, Zhi-Shu Huang, Qingjiang Li, Honggen Wang*. Radical Borylative Cyclization of Isocyanoarenes with N-Heterocyclic Carbene Borane: Synthesis of Borylated Aza-arenes. Org. Lett. 2021, 23, 1891–1897.

16. Ling Yang, Dong-Hang Tan, Wen-Xin Fan, Xu-Ge Liu, Jia-Qiang Wu, Zhi-Shu Huang, Qingjiang Li, Honggen Wang. Photochemical Radical C-H Halogenation of Benzyl N‐Methyliminodiacetyl (MIDA) Boronates: Synthesis of α-Functionalized Alkyl Boronates.  Angew. Chem. Int. Ed. 2020, 60, 3454-3458.

17. Yao-Fu Zeng, Xu-Ge Liu, Dong-Hang Tan, Wen-Xin Fan, Yi-Na Li, Yu Guo, Honggen Wang. Halohydroxylation of alkenyl MIDA boronates: switchable stereoselectivity induced by B(MIDA) substituent. Chem. Commun,, 2020, 56, 4332-4335.

18. Xiang-Lei Han, Xu-Ge Liu, E Lin, Yunyun Chen, Zhuangzhong Chen, Honggen Wang, Qingjiang Li.*Cp*Co(III)-Catalyzed oxidative [5+2] annulation: regioselective synthesis of 2-aminobenzoxepines via C–H/O–H functionalization of 2-vinylphenols with ynamides, Chem. Commun., 2018, 54, 11562-11565 .

19. Shang-Shi Zhang, Xu-Ge Liu, Shi-Yong Chen, a Dong-Hang Tan, Chun-Yong Jiang, Jia-Qiang Wu, Qingjiang Li,* and Honggen Wang,* (Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Oxidative [4+2] Annulation of N-H Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines. Adv. Synth. Catal. 2016, 358, 1705–1710. (IF 6.453)

20. Shang-Shi Zhang, Jia-Qiang Wu, Xuge Liu, and Honggen Wang*, Tandem Catalysis: Rh(III)-Catalyzed C–H Allylation/Pd(II)-Catalyzed N-Allylation Toward the Synthesis of Vinyl-Substituted N-Heterocycles. ACS Catal. 2015, 5, 210–214. (IF 9.307)

21. Ye-Xing Lao, Shang-Shi Zhang, Xu-Ge Liu, Chun-Yong Jiang, Jia-Qiang Wu, Qingjiang Li, Zhi-Shu Huang, and Honggen Wang.* High-Valent Pentamethylcyclopentadienylcobalt(III) or -iridium(III)-Catalyzed C-H Annulation with Alkynes: Synthesis of Heterocyclic Quaternary Ammonium Salts. Adv. Synth. Catal. 2016, 358, 2186–2191. (IF 6.453)

22. Shi-Yong Chen, Qingjiang Li*, Xu-Ge Liu, Jia-Qiang Wu, Shang-Shi Zhang, Honggen Wang*. Polycyclization Enabled by Relay Catalysis: One-Pot Manganese-Catalyzed C−H Allylation and Silver-Catalyzed Povarov Reaction. ChemSusChem. 2017, 10, 2360-2364. (IF 7.226)

23. Xiang-Lei Han, Chu-Jun Zhou, Xu-Ge Liu, Shang-Shi Zhang, Honggen Wang, * Qingjiang Li. * Regioselective Synthesis of 5-Aminooxazoles via Cp*Co(III)-Catalyzed Formal [3 + 2] Cycloaddition of N-(Pivaloyloxy)amides with Ynamides. Org. Lett. 2017, 19, 6108-6111.

24. Shang-Shi Zhang, ‡ Jie Xia, ‡ Jia-Qiang Wu, Xu-Ge Liu, Chu-Jun Zhou, E. Lin, Qingjiang Li, Shi-Liang Huang, * Honggen Wang. * Three-Component Catalytic Carboxygenation of Activated Alkenes Enabled by Bimetallic Rh(III)/Cu(II) Catalysis. Org. Lett. 2017, 19, 5868-5871.

25. Shang-Shi Zhang, ‡ Chun-Yong Jiang, ‡ Jia-Qiang Wu, Xu-Ge Liu, Qingjiang Li, Zhi-Shu Huang, Ding Li,* Honggen Wang.* Cp*Rh(III) and Cp*Ir(III)-Catalysed Redox-Neutral C-H Arylation with Quinone Diazides: Quick and Facile Synthesis of Arylated Phenols. Chem. Commun. 2015, 51, 10240-10243.

26. Yao-Fu Zeng, Dong-Hang Tan, Yunyun Chen, Wen-Xin Lv, Xu-Ge Liu, Qingjiang Lia  and   Honggen Wang*. Direct radical trifluoromethylthiolation and thiocyanation of aryl alkynoate esters: mild and facile synthesis of 3-trifluoromethylthiolated and 3-thiocyanated coumarins. Org. Chem. Front. 2015, 2, 1511-1515.

27. Shang-Shi Zhang, Jia-Qiang Wu, Ye-Xing Lao, Xu-Ge Liu, Yao Liu, Wen-Xin Lv, Dong-Hang Tan, Yao-Fu Zeng, and Honggen Wang*, Mild Rhodium(III)-Catalyzed C–H Allylation with 4-Vinyl-1,3-dioxolan-2-ones: Direct and Stereoselective Synthesis of (E)-Allylic Alcohols, Org. Lett. 2014, 16, 6412−6415.

28. Fan Yang, Liang Feng, Nengzhong Wang, Xuge Liu, Jun Li, Yuehai Shen *Practical synthesis of C1-8 fragment of autolytimycin via a chelation-controlled diastereoselective addition of diisopropenylzinc to α-methoxy aldehyde. Tetrahedron. 2013, 69, 9463-9468.

科研项目:

1. 国家自然科学基金-青年科学基金：廉价金属催化的基于惰性键活化的碳苷合成新策略和新方法2019.1-2021.12.  26万 项目批准号：21801256（主持）

2. 广东省自然科学基金-面上项目：基于钴催化酸脱羧及惰性键活化策略合成碳苷新方法2019.10-2023.09，10 万 项目批准号：2019A1515011170（主持）

3. 中山大学青年教师培育项目：基于钴催化糖醛酸脱羧策略合成碳苷新方法研究， 2019.01-2021.12，15万 项目批准号：19ykpyl33（主持）

4. 河南省高校重点研究项目：还原偶联策略在糖苷合成中的应用，2023.01-2024.12，3万 项目批准号：23A350003 （主持）

5. 国家自然科学基金-面上项目：基于sp3-硼活化不饱和体系的有机硼构建：“沉默-活化”策略的探究及应用，2020.01-2023.12，65万，项目批号：21971261 （参与）

6. 国家自然科学基金：基于金催化串联反应的天然产物Ganocins A-C全合成及生物学活性研究 2016.1-2018.12. 项目批准号：21502242（参与）

7. 国家自然科学基金：δ、μ、κ阿片受体三重激动剂的作用机制研究2012.1-2012.12. 项目批准号：81173029（参与）

发明专利：

1. 王洪根，刘许歌，李清江；一种丙克拉莫中间体的合成方法中国发明专利申请, 申请号 CN201810876659.1授权公告号CN109251164A

2. 沈悦海, 崔本强, 伊首璞, 刘许歌, 杨帆, 张宽仁; 一类含饱和氮杂环酰胺的二芳基甲基哌嗪化合物及其应用. 中国发明专利申请, 申请号 2013104343006, 授权公告号CN103467391B.

3. 沈悦海, 崔本强, 伊首璞, 刘许歌, 杨帆, 张宽仁; 一类含噻吩环和苄基的二芳基甲基哌嗪化合物及其应用. 中国发明专利申请, 申请号 2013104353008, 授权公告号CN103467460A.

4. 李清江，王洪根，冯嗣欣，刘晓彬，刘许歌，“一类1-芳基取代的（顺，顺）-2-叠氮-1，3-二氟化合物及其制备方法”，中国发明专利，授权，2023.05.09，ZL 202210765695.7.