人才队伍

基本情况：

金万洙，博士。中国科学院动物研究所研究员、博士生导师。研究方向主要包括慢性疾病治疗、肿瘤免疫和小分子靶点药物筛选工作，采用基因分析、动物模型、细胞和分子技术等多种方法进行研究，寻找内分泌调控的新型干预策略对肥胖、糖尿病和慢性肝病进行治疗。先后主持国家自然科学基金面上项目 3 项，国家自然科学基金重大项目 1 项，中国科学院院重点部署项目 1 项；作为课题负责人承担国家重点基础研究发展计划（973 计划） 1 项、中国科学院战略先导专项 1 项；参与国家重点基础研究发展计划（973 计划） 1 项、国家重点研发计划 1 项。在棕色脂肪的生理作用、棕色脂肪激活剂的筛选、棕色脂肪与肠道菌群及肝脏之间的交互调控等方面取得了多项原创性成果，并受邀担任Front Endocrinol杂志Obesity副主编和Biology编委。已在J Med Virol、Adv Sci、Gut、PNAS、Cell Res、JCI、Dev Cell、Endocrinology等刊物上发表SCI收录论文60余篇，其中通讯或共同通讯作者文章20余篇，获批专利6项。

近5年来通讯作者文章：

(1) Zhao Yiming#, Zhang hanlin#, Zhao Zhizhuang#, Liu Fangfang#, Dong Meng#, Chen Li#, Shen Mingzhi#, Luan Zhe#, Zhang Hanwen, Wu Junling, Li Congyong, Chen Jun, Li Chao, Liu Zhiwei, Chen Yi, Zheng Aihua, Li Huiling*, Wang Shufang*, Jin Wanzhu*, Sun Gang*. Efficacy and safety of Oral LL-37 against the Omicron BA.5.1.3 variant of SARS-COV-2: A randomized trial. J Med Virol, 2023 Aug;95(8):e29035.

 (2) Ye Rongcai#, Yan Chunlong#, Zhou Huiqiao#, Zhang Chuaihai, Huang Yuanyuan, Dong Meng, Zhang Hhanlin, Lin Jun, Jiang Xiaoxiao, Yuan Shouli, Chen Li, Jiang Rui, Cheng Ziyu, Zheng Kexin, Yu Anni, Zhang Qiaoli*, Quan Linhu*, Jin Wanzhu*. Brown adipose tissue activation with ginsenoside compound K ameliorates polycystic ovary syndrome. Br J Pharmacol, 2022 Sep;179(18):4563-4574.

(3) Jiang Xiaoxiao#, Lin Jun#, Dong Meng, Liu Xiaomeng, Huang Yuanyuan, Zhang Hanlin, Ye Rongcai, Zhou Huiqiao, Yan Chunlong, Yuan Shouli, Chen Li, Jiang Rui, Zheng Kexin, Jin Wanzhu. Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime. Front Physiol, 2022; 13: 950619.

(4) Zhou Huiqiao#, Zhang Hanlin#, Ye Rongcai#, Yan Chunlong#, Lin Jun, Huang Yuanyuan, Jiang Xiaoxiao, Yuan Shouli, Chen Li, Jiang Rui, Zheng Kexin, Cheng Ziyu, Zhang Zhi, Dong Meng*, Jin Wanzhu*. Pantothenate protects against obesity via brown adipose tissue activation. Am J Physiol Endocrinol Metab, 2022 Jul 1;323(1):E69-E79.

(5)  Yan Chunlong#, Lin Jun#, Huang Yuanyuan#, Gao Qingshan#, Piao Zhengyu#, Yuan Shouli, Chen Li, Ren Xue, Ye Rongcai, Dong Meng, Zhang Hanlin, Zhou Huiqiao, Jiang Xiaoxiao, Jin wanzhu*, Zhou Xuming*, Yan Changguo*. Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle. Zoological Research, 2022, 43(2): 275-284.

(6) Yuan Shouli#, Dong Meng, Zhang Hanlin, Jiang Xiaoxiao, Yan Chunlong, Ye Rongcai, Zhou Huiqiao, Chen Li, Lian Huiru, Jin Wanzhu*; Ginsenoside PPD inhibit the activation of HSCs by directly targeting TGFβR1, Int J Biol Macromol, 2022;194:556-562.

 (7) Lin Jun#, Jiang Xiaoxiao#, Dong Meng, Liu Xiaomeng, Shen Qiwei, Huang Yuanyuan, Zhang Hanlin, Ye Rongcai, Zhou Huiqiao, Yan Chunlong, Yuan Shouli, Wu Xiangnan, Chen Li, Wang Yanfang, He Min, Tao Yi, Zhang Zhaoyun*, Jin Wanzhu*. Hepatokine Pregnancy Zone Protein Governs the Diet-Induced Thermogenesis Through Activating Brown Adipose Tissue. Adv Sci (Weinh), 2021 Nov;8(21):e2101991.

(8) Ye Rongcai#, Yan Chunlong#, Zhou Huiqiao#, Huang Yuanyuan, Dong Meng, Zhang Hanlin, Jiang Xiaoxiao, Yuan Shouli, Chen Li, Jiang Rui, Cheng Ziyu, Zheng Kexin, Zhang Qiaoli*, Jin Wanzhu*. Brown Adipose Tissue Activation by Cold Treatment Ameliorates Polycystic Ovary Syndrome in Rat. Front Endocrinol, 2021 Oct 14;12:744628.

(9) Yuan Shouli#, Dong Meng#, Zhang Hanlin#, Xu Hongde#, Wang Qi#, Yan Chunlong, Ye Rongcai, Jiang Xiaoxiao, Zhou Huiqiao, Chen Li, Cheng Jun*, Xie Wen*, Jin Wanzhu*. Oral delivery of a Lactococcus lactis expressing extracellular TGFβR2 alleviates hepatic fibrosis. Appl Microbiol Biotechnol, 2021, 105(14-15):6007-6018.

(10) Quan Lin-Hu#, Zhang Chuanhai#, Dong Meng#, Jiang Jun#, Xu Hongde#, Yan Chunlong#, Liu Xiaomeng, Zhou Huiqiao, Zhang Hanlin, Chen Li, Zhong Feiliang, Luo Zhaobo, Lam Sin-Man, Shui Guanghou, Li Donghao*, Jin Wanzhu*. Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. Gut, 2020, 69(7): 1239-1247. 

(11) Huang Yuanyuan, Zhang Hanlin, Dong Meng, Zhang Lei, Lin Jun, Ye Rongcai, Zhou Huiqiao, Liu Xiaomeng*, Jin Wanzhu*. miR17-92 cluster drives white adipose tissue browning. J Mol Endocrinol, 2020, 65, 97-107.

(12) Yin Na#, Zhang Hanlin, Ye Rongcai, Dong Meng, Lin Jun, Zhou Huiqiao, Huang Yuanyuan, Chen Li, Jiang Xiaoxiao, Kentaro Nagaoka, Zhang Chuanhai*, Jin Wanzhu*. Fluvastatin Sodium Ameliorates Obesity through Brown Fat Activation. Int J Mol Sci, 2019, 20(7): pii: E1622.

近5年来获得专利：

（1）金万洙，蒋笑笑，严春龙。一种重组乳酸乳球菌、微胶表及其应用：中国，申请号:202210086687X。

（2）金万洙，董孟，张瀚林，程子昱。一种表达VEGFR3 D2多肽的细菌制剂及其构建方法和应用：中国，ZL202210191147.8。

（3）金万洙，林骏，蒋笑笑。PZP的用途以及包括PZP的用于抵抗肥胖的药物组合物：中国，ZL202111056551.6。

（4）金万洙，张瀚林，蒋笑笑，郑爱华。一种表达LL-37多肽的重组表达载体、重组乳酸乳球菌、抗病毒药物及构建方法和应用：中国，ZL202010313254.4。

（5）金万洙，一种组成型乳酸菌启动子、重组载体及其重组菌和应用：中国，ZL201910288779.4。

（6）金万洙，肉豆蔻脑酸甲酯在制备预防或治疗代谢综合征或改善机体能量代谢的产品中的应用：中国，ZL201810006969.8。