人才队伍

2、主要研究方向：糖化学与糖生物学、药物化学、化学生物学、抗肿瘤药物药理学

3、承担的研究项目：

(1)国家自然科学基金，国家级，批准时间：2018年8月17日，主持

(2)省级科技研发计划联合基金青年科学家项目（省优青），省部级，批准时间：2023年6月23日，主持

(3)16批博后特别资助，国家级，批准时间：2023年8月1日，主持

(4)首批中州实验室“青年人才提升计划”（50 万/项），其他，批准时间：2024年5月1日，主持

(5)64批面上基金，国家级，批准时间：2018年11月1日，主持

(6)70批面上基金，国家级，批准时间：2021年11月07日，主持

(7)河南省科技厅科技攻关项目，省部级，批准时间：2019年12月31日，主持

(8)河南省科技厅科技攻关项目，省部级，批准时间：2022年01月01日，主持

(9)河南省自然基金，省部级，批准时间：2023年03月22日，主持

(10)河南省高等学校重点科研项目，厅级，批准时间：2021年11月07日，主持

(11)河南省高等学校重点科研项目，厅级，批准时间：2018年6月27日，主持

(12)河南省博士后基金，厅级，批准时间：2018年6月19日，主持

(13)河南大学青年人才专项科研培育计划，其他，批准时间：2019年7月5日，主持

(14)河南大学青年人才专项科研培育计划，其他，批准时间：2022年7月1日，主持

(15)河南大学博士启动金一等资助，其他，批准时间：2017年9月1日，主持

(16)2019年省拨64批面上资助匹配资助，其他，批准时间：2019年11月12日，主持

(17)2021年省拨70批面上资助匹配资助，其他，批准时间：2018年11月1日，主持

(18)2023年省拨特别资助匹配资助，其他，批准时间：2023年7月1日，主持

(19)河南大学博士启动金，其他，批准时间：2017年9月，主持

4、已发表论文：

[1] Jing Ma, Yutong Chen, Tao Li, Jianing Liu, Wei Zhang, Yi Cao, Bin Hu, Hanjing Niu, Jinhua Gao, Zhongze Zhang, Kexin Yue, Guochen Bao, Jiajia Wang, Chaojie Wang, Peng George Wang, and Songqiang Xie.* Suppression of lysosome metabolism-meditated GARP/TGF-β1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis. Oncogene, 2024, doi: 10. 1038/s41388-024-03043-y. (SCI一区TOP，IF = 10.00，一作，Springer Nature)

[2] Jing Ma, Ruijuan Ma, Xueke Zeng, Liming Zhang, Hanjing Niu, Jianing Liu, Tao Li, Wei Zhang, Yi Cao, Bin Hu,Jinhua Gao, Zhongze Zhang, Lili Hou, Guochen Bao, Chaojie Wang, Peng George Wang, Jiajia Wang,* Xia Li,* Taotao Zou, and Songqiang Xie.* Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy. J EXP CLIN CANC RES. 2023, 42, 192. (SCI一区TOP，IF = 12.6 ，一作)

[3] Jing Ma, Suppression of Polyamine Uptake and ODC-mediated Complex Type N-glycan in PD-L1 Remodels Immunosuppressive Microenvironment in Non-small Cell Lung Cancer. Nature Chemical Biology, Major Revision. (SCI一区TOP，IF = 16.17, Nature子刊)

[4] Wang J, Cao W, Zhang W, Dou B, Ding X, Wang M, Ma J*, Li X*. Tumor-Targeted Oxaliplatin(IV) Prodrug Delivery Based on ROS-Regulated Cancer-Selective Glycan Labeling. Journal of Medicinal Chemistry 2024, doi: 10. 1021/acs.jmedchem.4c00459. (SCI一区TOP期刊，IF= 8.1)

[5] Hanfang Liu,# Jing Ma,#* Yingguang Li, Kexin Yue, Linrong Li, Zhuoqing Xi, Xiao Zhang, Jianing Liu, Kai Feng, Qi Ma, Sitong Liu, Shudi Guo, Peng George Wang, Chaojie Wang,* and Songqiang Xie.* Polyamine-based Pt(IV) Prodrugs as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Metastases as DNA and Polyamine Metabolism Dual-Targeted Antimetastatic Agents. Journal of Medicinal Chemistry 2019, 62, 11324-11334. (他引16次，SCI一区TOP期刊，IF= 8.1,一作兼第一通讯)

[6] Jing Ma, Qingpeng Wang, Zhonglv Huang, Xiande Yang, Wenpei Hao, Xin Wang*, Peng George Wang*. Glycosylated Platinum(IV) Complexes as Substrates for Glucose Transporters (GLUTs) and Organic Cation Transporters (OCTs) Exhibited Cancer Targeting and Human Serum Albumin Binding Properties for Drug Delivery.Journal of Medicinal Chemistry 2017, 60, 5736-5748.（SCI一区TOP期刊，IF= 8.1, 一作）（他引80次，其中包括Chemical Reviews, IF=51.08; Molecular cancer, IF=15.30等，研究成果并被写入金属类药物著名系列丛书METALLO-DRUGS: DEVELOPMENT AND ACTION OF ANTICANCER AGENTS 丛书: MetalIonsin Life Sciences）

[7] Shihao Su,# Yutong Chen,# Pengfei Zhang,# Ruijuan Ma,# Wei Zhang, Jianing Liu, Tao Li, Hanjing Niu, Yi Cao, Bin Hu, Jinhua Gao, Hua Sun, Dong Fang, Jiajia Wang, Peng George Wang, Songqiang Xie,* Chaojie Wang,* and Jing Ma.* The Role of Platinum(IV)-Based Antitumor Drugs and the Anti-cancer Immune Response in Medicinal Inorganic Chemistry. A Systematic Review from 2017 to 2022. European Journal of Medicinal Chemistry, 2022, 243，114680. (SCI一区TOP期刊，IF= 7.1,邀请综述)

[8] Jing Ma, Xiande Yang, Wenpei Hao, Zhonglv Huang, Xin Wang*, Peng George Wang*. Mono-functionalized glycosylated platinum(IV) complexes possessed both pH and redox dual-responsive properties: Exhibited enhanced safety and preferentially accumulated in cancer cells in vitro and in vivo. European Journal of Medicinal Chemistry 2017, 128, 45-55.（他引32次，SCI一区TOP期刊，IF= 7.1,一作）

[9] Jing Ma#, Linrong Li#, Kexin Yue, Zhansheng Zhang, Shihao Su, Yutong Chen, Lu Yu, Pengfei Zhang, Ruijuan Ma, Yingguang Li, Yinxia Ma, Huinan Jia, Chaojie Wang, Jiajia Wang*, and Songqiang Xie*. A Naphthalimide-Polyamine Conjugate Preferentially Accumulates in Hepatic Carcinoma Metastases as a Lysosome-Targeted Anti-metastatic Agent. European Journal of Medicinal Chemistry 2021, 221, 113469.（SCI一区TOP期刊, IF= 7.1,第一作者）

[10] Jing Ma, LinrongLi, KexinYue, YingguangLi, HanfangLiu, Peng GeorgeWang, ChaojieWang, JiajiaWang *, WenLuo *, SongqiangXie*. Bromocoumarinplatin, Targeting Simultaneous Mitochondrion and Cell Nucleus with p53 Apoptosis Pathway to Overcome Cisplatin Resistance. Bioorganic chemistry 2020, 99, 103768.（SCI二区TOP期刊，第一作者）

[11] Yingguang Li#, Kexin Yue#, Linrong Li#, Jie Niu, Hanfang Liu, Jing Ma*, and Songqiang Xie*. A Pt(IV)-based Mononitro-naphthalimide Conjugate with Minimized Side-effects Targeting DNA Damage Response via a Dual-DNA-Damage Approach to Overcome Cisplatin Resistance. Bioorganic chemistry 2020, 101, 104011.（SCI二区TOP期刊，第一通讯作者）

[12] Jiajia Wang, Wei Cao, Wei Zhang, Xueke Zeng, Shihao Su, Hongtai Cao, Xin Ding, Jing Ma*, Biao Dou*, XiaLi*.Ac34FGlcNAz Is an Effective Metabolic Chemical Reporter for O-GlcNAcylated Proteins with Decreased S-glyco-modification. Bioorganic chemistry 2022, 131, 106139.（SCI二区TOP期刊，第一通讯作者）

[13] Jing Ma, Qing-Peng Wang, Xiande Yang, Wenpei Hao, Zhonglv Huang, Jiabao Zhang, Xin Wang* ，Peng George Wang*. Glycosylated platinum(IV) prodrugs demonstrated significant therapeutic efficacy in cancer cells and minimized side-effects. Dalton Transactions 2016, 45(29), 11830-11838. （SCI无机化学TOP期刊，一作）

[14] Depu Song, Tengli Ding, Weibin Zhai, Lulian Shao, Ning Guo, Lei Jiang, Wei Zhang, Fenqin Zhao, Jianhong Wang, Junfeng Wang, Jing Ma*, and Lin Yan.* Design, synthesis and biological evaluation of small molecular fluorescent probes targeting EGFR for tumor detection and treatment. Analyst, 2023, 148, 6325-6333.（SCI二区，一作）

[15] Jing Ma, Hanfang Liu, Zhuoqing Xi, Jiuzhou Hou, Yingguang Li, Jie Niu, Tong Liu, Shuning Bi, Xin Wang, Chaojie Wang, Jiajia Wang,* Songqiang Xie,* Peng George Wang*. Protected and de-protected platinum(IV) glycoconjugates with GLUT1 and OCT2-mediated selective cancer targeting: demonstrated enhanced transporter-mediated cytotoxic properties in vitro and in vivo. Front. Chem., 2018, 6, 386.（SCI二区，一作）

[16] Jing Ma,# Yingguang Li,# Linyong Li, Kexin Yue, Hanfang Liu, Zhuoqing Xi, Qi Ma, Sitong Liu, Shudi Guo, Jianing Liu, Chaojie Wang, Peng George Wang, Jiajia Wang*, Zhiyong Tian,* and Songqiang Xie.* A Polyamine-based Dinitro-naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side-effects in vitro and in vivo. Front. Chem., 2020, 8 ，166.（SCI二区，一作）

[17] Xiao Wang, Chao Liang, Xin Yao, Ruo-Han Yang, Zhan-Sheng Zhang, Fan-Ye Liu, Wen-Qi Li, Shu-Hua Pei, Jing Ma*, Song-Qiang Xie* and Dong Fang*. PKM2-induced the phosphorylation of histone H3 contributes to EGF-mediated PD-L1 transcription in HCC. Front Pharmacol. 2020, 11, 577108.（SCI二区，TOP期刊，第一通讯作者）

[18] Jiajia Wang, Biao Dou, Lu Zheng, Wei Cao, Peiyu Dong, Yingyi Chen, Xueke Zeng, Yinhang Wen, Wenxuan Pan, Jing Ma*, Jingying Chen* and Xia Li*. The Metabolic Chemical Reporter Ac 4 6AzGal Could Incorporate Intracellular Protein Modification Mediated by OGT/OGA and Enzymes in Leloir Pathway. Front. Chem., 2021, 9, 708306. (SCI二区，第一通讯作者)

[19] Jiajia Wang, Wei Zhang, Wei Cao, Kang Liu, Shihao Su, Jing Ma* and Xia Li*. Selective synthesis of α- and β-glycosides of N-acetyl galactosamine using rare earth metal triflates. Front. Chem. 2022, 10, 1029911. (SCI二区， 第一通讯作者)

[20] Tian Z, Ding T, Niu H, Wang T, Zhang Z, Gao J, Kong M, Ming L, Tian Z, Ma J, Luo W, Wang C. 2-Phenylquinoline-polyamine conjugate (QPC): Interaction with bovine serum albumin (BSA). Spectrochim Acta A Mol Biomol Spectrosc. 2023, 300, 122875. (SCI二区，第一通讯作者)

[21] Wang J, Zhang D, Wen Y, Cao X, Ma J*, George Wang P*. Efficient chemoenzymatic synthesis of UDP-α-6-N3-glucose. Bioorg Med Chem Lett. 2019, 29(9):1148-1151.（SCI三区，第一通讯作者）

[22] Wen Luo, Jian-Wu Lv, Ting Wang, Zhi-Yang Zhang, Hui-Yan Guo, Zhi-Yi Song, Chaojie Wang, Jing Ma*, yiping chen*. Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents. Bioorg Med Chem, 2020 ，28(1):115190.（SCI三区，第一通讯作者）

[23] Jiajia Wang, Yinhang Wen, Lu Zheng, Biao Dou, Linrong Li, Kangkang Zhao, Na Wang, Jing Ma*. Characterization of chemical profiles of pH-sensitive cleavable D-gluconhydroximo-1, 5-lactam hydrolysates by LC–MS: A potential agent for promoting tumor-targeted drug delivery. Journal of Pharmaceutical and Biomedical Analysis 185 (2020)113244.（SCI二区，第一通讯作者）

[24] Fenqin Zhao, Jinyu Li, Kexin Yue, Beibei Song, Erying Sun, Xinru Cheng, Jing Ma * and Lin Yan *. Design, Synthesis, and Cell Lines Studies of Oleanolic Acid—Hydrogen Sulfide Donor Hybrids. Appl. Sci. 2021, 11, 3364.（SCI三区，第一通讯作者）

[25] Jianing Liu, Yi Cao, Bin Hu, Tao Li, Wei Zhang, Zhongze Zhang, Jinhua Gao, Hanjing Niu, Tengli Ding, Jinzhong Wu,Yutong Chen, Pengfei Zhang, Ruijuan Ma, Shihao Su, Chaojie Wang, Peng George Wang, Jing Ma* and Songqiang Xie*. Older but Stronger: Development of Platinum-Based Antitumor Agents and Research Advances in Tumor Immunity. Inorganics 2023, 11, 145.

[26] Wang J, Dou B, Zheng L, Cao W, Zeng X, Wen Y, Ma J*, Li X*. Synthesis of Na2S2O4 mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition. Bioorg Med Chem Lett. 2021, 48, 128244

5、专利授权：

(1)王欣*，王鹏*，马静.具有抗癌活性的糖基化四价铂类化合物、制备方法及应用. 专利号: ZL 2016 1 0084260.0

(2)马静，谢松强，王超杰，刘瀚方. 专利《一种四价铂多胺配合物、其制备方法及应用》. 201810980644.X.20200529（第一发明人）

(3)马静，王佳佳，方东，孙华，谢松强，李迎光，李林容，岳柯欣.  一种四价铂萘酰亚胺配合物、其制备方法及应用, 2021-09-10, ZL202010369930.X. 20210910（第一发明人）

(4)马静，王佳佳，田智勇，方东，孙华，谢松强。一种萘酰亚胺吲哚杂环化合物、其制备方法及应用。202110125413.2. 20220308 （第一发明人）

(5)马静，王佳佳，孙华，方东，谢松强.一种基于多胺修饰的萘酰亚胺缀合物、其制备方法及应用 CN 112876414B. 20220909（第一发明人）

(6)马静，王佳佳，方东，孙华，谢松强.  一种糖基修饰的萘酰亚胺-多胺缀合物、其制备方法及应用 CN112940059 B. 20220527（第一发明人，已授权）

(7)马静，王佳佳，谢松强，方东，孙华，王超杰，曹怡，胡彬一种基于调控Mucin型O-糖基化靶向CRPC的四价铂氨基己糖配合物及其应用.CN 116621900 B 20240507（第一发明人，已授权）

(8)王佳佳，李霞，马静，王鹏。4-脱氧-N-乙酰氨基葡萄糖作为革兰氏阴性菌抗菌添加剂的应用。 CN113413390 B.20220830

6、联系方式（邮箱等）：majing@henu.edu.cn