人才队伍

郑善清，博士，教授，河南大学高层次人才黄河学者。

2010-2013，中国科学院大学，博士

2014-2019，女王大学(Queen’s University, Canada)，博士后

2019至今，河南大学基础医学院，教授

2、主要研究方向：

    目前主要研究营养与衰老及衰老相关疾病的关系，其中包括营养因子、维生素和氨基酸单体等对衰老的影响；核糖体、蛋白质稳态与长寿的关系；以及间歇性节食对衰老和健康的影响。

3、已发表论文：

[1] Xue Yin, Fangzhou Dai, Dongyang Ran, Yutong Zhang, Zhi Qu, Shanqing Zheng. Cysteine protease cathepsin B promotes lysosome integrity to extend the lifespan of alternative day fasting worms. Aging Cell. 2024;00:e14286. DOI: 10.1111/acel.14286 (2024). 通讯作者，一区TOP，IF 8.0

[2] Wei Zhao, Ruiting Huang, Dongyang Ran, Yutong Zhang, Zhi Qu, Shanqing Zheng. Inhibiting HSD17B8 suppresses the cell proliferation caused by PTEN failure. Scientific Reports, (2024) 14:12280, doi:10.1038/s41598-024-63052-5. 通讯作者，二区，IF 4.60

[3] Zhi Qu, Limin Liu, Xiaoliang Wu, Peisen Guo, Zengli Yu, Peixi Wang, Yuzhen Song, Shanqing Zheng & Nan Liu. Cadmium-induced reproductive toxicity combined with a correlation to the oogenesis process and competing endogenous RNA networks based on a Caenorhabditis elegans model. Ecotoxicology and Environmental Safety 268, doi:10.1016/j.ecoenv.2023.115687 (2023). 通讯作者，二区TOP，IF 6.800

[4] Zhi Qu, Lu Zhang, Wei Huang & Shanqing Zheng. Vitamin K2 Enhances Fat Degradation to Improve the Survival of C. elegans. Frontiers in Nutrition 9, doi:10.3389/fnut.2022.858481 (2022). 通讯作者，一区TOP，IF 6.590

[5] Zhi Qu, Chunqian Feng, Virginia K. Walker, Wenyi Kang, Nan Liu & Shanqing Zheng. Effects of sugar addition on adipolysis and volatile profiles of dry cured sausage. Journal of Future Foods 2, 184-191, doi:10.1016/j.jfutfo.2022.03.001 (2022). 通讯作者，IF 5.20

[6] Zhi Qu, Chunqian Feng, Ruiling Li, Nan Liu & Shanqing Zheng. Characteristic and effect analysis of protein and peptide in Cantonese cured meat processing. Food Science and Human Wellness 11, 1392-1401, doi:10.1016/j.fshw.2022.04.028 (2022).通讯作者，一区TOP，IF 8.022

[7] Zhi Qu, Shaoping Ji & Shanqing Zheng. Glucose and cholesterol induce abnormal cell divisions via DAF-12 and MPK-1 in C. elegans. Aging-Us 12, 16255-16269 (2020). 通讯作者，二区TOP，IF 5.682

[8] Zhi Qu, Shaoping Ji & Shanqing Zheng. BRAF Controls the Effects of Metformin on Neuroblast Cell Divisions in C. elegans. International journal of molecular sciences 22, doi:10.3390/ijms22010178 (2020). 通讯作者，二区TOP，IF 5.923

[9] Shanqing Zheng, Zhi Qu, Michael Zanetti, Brandon Lam & Ian Chin-Sang. C. elegans PTEN and AMPK block neuroblast divisions by inhibiting a BMP-insulin-PP2A-MAPK pathway. Development 145, doi:10.1242/dev.166876 (2018). 第一作者，二区TOP，IF 6.868

[10] Shanqing Zheng, Hilton Chiu, Jeffrey Boudreau, Tony Papanicolaou, William Bendena & Ian Chin-Sang. A functional study of all 40 Caenorhabditis elegans insulin-like peptides. The Journal of biological chemistry 293, 16912-16922, doi:10.1074/jbc.RA118.004542 (2018). 第一作者，二区TOP，IF 5.157

[11] Shanqing Zheng, Xiaobing Huang, Tikun Xing, Aijun Ding, Guisheng Wu & Huairong Luo. Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. The journals of gerontology. Series A, Biological sciences and medical sciences 72, 464-472, doi:10.1093/gerona/glw105 (2017). 第一作者，一区TOP，IF 6.053

[12] Shanqing Zheng & Ian D. Chin-Sang. C. elegans Methods to Study PTEN. Methods in Molecular Biology, 307-321, doi:10.1007/978-1-4939-3299-3_17 (2016).

[13] Shanqing Zheng, Sentai Liao, Yuxiao Zou, Zhi Qu, Weizhi Shen & Ying Shi. Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719, doi:10.1007/s11357-014-9719-z (2014). 通讯、第一作者，二区，IF 3.390

[14] Shanqing Zheng, Sentai Liao, Yuxiao Zou, Zhi Qu & Fan Liu. ins-7 Gene expression is partially regulated by the DAF-16/IIS signaling pathway in Caenorhabditis elegans under celecoxib intervention. PloS one 9, e100320, doi:10.1371/journal.pone.0100320 (2014). 通讯、第一作者，三区，IF 3.23

[15] Shanqing Zheng, Aijun Ding, Guoping Li, Guisheng Wu & Huairong Luo. Drug absorption efficiency in Caenorhbditis elegans delivered by different methods. PloS one 8, e56877, doi:10.1371/journal.pone.0056877 (2013).第一作者，三区，IF 3.53

4、联系方式（邮箱等）：zhengshanqing@henu.edu.cn