1、个人简介:周云丰,博士,副教授,硕士生导师,中国中医药信息学会科技创新与成果转化分会理事、河南省药学会中药资源专业委员会秘书。
2、主要研究方向:
神经精神疾病的发病机理及中药干预机制
3、承担的研究项目:
(1)远志寡糖酯调控线粒体自噬-突触可塑性发挥抗抑郁作用的机制研究,国家自然科学基金青年项目,82104415,2022.01-2024.12,主持。
(2)远志中寡糖酯有效部位的开发及其在改善抑郁方面的应用,河南省高等学校重点科研项目,22A360001,2022.01-2023.12,主持。
(3)基于神经血管单元稳态调控探讨远志寡糖酯有效部位“交通心肾”改善抑郁的机制,中国博士后科学基金第70批面上项目,2021M701095,2021.03-2022.12,主持。
(4)基于调控线粒体自噬新思路的三乙酰穿心莲内酯抗AD创新药物开发,,河南省重点研发与推广专项(科技攻关)项目,222102310114,2022.01-2023.12,主持。
4、已发表论文:
[1] Zhou YF*, Zhao Q*, Zhang Y*, Di L, Xue F, Xu W, Gao W, Guo Y, He Y, Kou J, Qin Y, Xie X, Du L, Han G, Pang X. A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice. Phytomedicine. 2024;124:155298. DOI: 10.1016/j.phymed.2023.155298.
[2] Xu W, Gao W, Guo Y, Xue F, Di L, Fang S, Fan L, He Y, Zhou YF#, Xie XM#, Pang XB#. Targeting mitophagy for depression amelioration: a novel therapeutic strategy. Front Neurosci, 2023;17:1235241. DOI: doi: 10.3389/fnins.2023.1235241.
[3] Liu PF*, Zhou YF*, Shi JZ, Wang F, Yang XJ, Zheng XH, Wang YR, He YY#, Xie XM#, Pang XB#. Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway. Phytomedicine. 2023;115:154801. DOI: 10.1016/j.phymed.2023.154801.
[4] Zhou YF*, Luo DM*, Shi JZ*, Yang XJ, Xu WJ, Gao WP, Guo YK, Zhao Q, Xie XM, He YY#, Du GH#, Pang XB#. Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin[J]. J Ethnopharmacol, 2023;312:116455. DOI: 10.1016/j.jep.2023.116455.
[5] Zhang HY, Xie XM, Shi JZ, Zhao Q, Luo DM, Hao JJ, Zhou YF#, Han G#, Pang XB#. 3, 14, 19-Triacetyl Andrographolide alleviates the cognitive dysfunction of 3 × Tg-AD mice by inducing initiation and promoting degradation process of autophagy[J]. Phytother Res, 2023; 37(2):410-423. DOI: 10.1002/ptr.7619.
[6] Zhou YF, Yan MZ, Pan RL, Wang Z, Tao X, Li CC, Xia TJ, Liu XM and Chang Q. Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation [J]. J Ethnopharmacol, 2021, 265: 113317. DOI: 10.1080/13880209.2021.1986077.
5、讲授课程:主讲《药用植物学》、《临床中药学》和《方剂学》等课程,参编学术著作/教材2部
6、联系方式(邮箱等):zyf@henu.edu.cn